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    June 17

    翁啟惠:肺癌等5種癌症 未來有分子疫苗

    翁啟惠:肺癌等5種癌症 未來有分子疫苗 中央社
    更新日期:2009/06/16 15:02
    (中央社記者林思宇台北16日電)中央研究院院長翁啟惠今天表示,最新研究成果發現,乳癌、肺癌、大腸癌、卵巢癌和攝護腺癌5種癌症,都有非常獨特的醣分子結構Globo-H,未來可以製作出分子疫苗預防。

    翁啟惠在中研院舉辦的「美洲華人生物科學學會第12屆國際研討會」上,發表「後轉譯的醣化─挑戰與機會」專題演講,會後接受媒體訪問時作上述表示。

    人類本身50%以上的蛋白質外圍會被醣分子包圍,病毒就利用醣分子包住自己來偽裝,使人類免疫系統無法辨識,翁啟惠的研究首度發現,去除不需要的醣蛋白上的醣分子,保留核心的醣分子和蛋白質,不會影響結構,而且能找出真正的抗原。

    翁啟惠發現,乳癌、肺癌、大腸癌、卵巢癌和攝護腺癌5種癌細胞表面的醣分子,是特殊的醣分子Globo-H,在正常人身上找不到,只有在癌細胞上才有,如果使用分子疫苗預防,人體免疫系統便可辨識出這是外來異常的細胞,免疫系統可直接把癌細胞殺掉,不會導致癌症。

    翁啟惠表示,針對這5種癌症,理論上可以做出預防性疫苗,但還需要經過人體試驗證明。980616

    

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